圖7. COX-2 (也稱為前列腺素 H 合成酶)的結構,其活性被阿斯匹靈給抑制了。這個酵素是一個二聚體,分別以藍色與綠色區分。每一個單體,活性位置上的絲氨酸已經被乙醯化,因此喪失其活性。同時我們可以見到每個單體上均有來自於水楊酸上的乙醯基,而血紅素為共結晶因子。 原文:Structure of COX-2( also called prostaglandin H synthase) inactivated by aspirin. The molecule is a dimer, the blue and green halves are identical. In each monomer, the active site serine has been acetylated, inactivating it. Also visible in each monomer is the salicylic acid from which the acyl group came, and the heme cofactor.(圖片來源:http://en.wikipedia.org/wiki/Aspirin) |